Chronic oxycodone induces axonal degeneration in rat brain
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چکیده
منابع مشابه
Chronic oxycodone induces axonal degeneration in rat brain
BACKGROUND Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, the correlation between opioid analgesics and alternations in brain structure, such as leukoencephalopathy, axon demyelination, and white matter lesions, has been demonstrated in patients with a history of long-term use of prescription opioids. The exact mechanisms u...
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Axonal degeneration in the central nervous system (CNS) is associated with neurologic disability. In some diseases, it has been postulated that axonal degeneration may be caused by loss of trophic support normally provided by oligodendrocytes and myelin. To investigate this phenomenon, we studied axonal pathology in the taiep mutant rat, which develops nonimmune oligodendrocyte dysfunction and ...
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Axonal damage is the major cause of irreversible neurologic disability in patients with multiple sclerosis. Although axonal damage correlates with antibodies against neurofilament light (NF-L) protein, a major component of the axonal cytoskeleton, the possible pathogenic role of autoimmunity to axonal antigens such as NF-L has so far been ignored. Here we show that Biozzi ABH mice immunized wit...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2018
ISSN: 1471-2202
DOI: 10.1186/s12868-018-0417-0